Virus schematic SARS-CoV2

 

A) Schematic representation of the genome organization and functional domains of S protein for COVID-19. The single-stranded RNA genomes of COVID-19 encode two large genes, the ORF1a and ORF1b genes, which encode 16 non-structural proteins (nsp1–nsp16). The structural genes encode the structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N). The accessory genes denoted in shades of green. The structure of S protein is shown beneath the genome organization. The S protein is consisting of the S1 and S2 subunits. The S1/S2 cleavage sites are highlighted by dotted lines. In the S-protein, cytoplasm domain (CP); fusion peptide (FP); heptad repeat (HR); receptor-binding domain (RBD); signal peptide (SP); transmembrane domain (TM) are shown B) The viral surface proteins, spike, envelope and membrane, are embedded in a lipid bilayer. The single-stranded positive-sense viral RNA is associated with the nucleocapsid protein.